R&D

New Paradigm for Stem Cell Technology

Proteome Profiling of Membrane-Free Stem Cell Components by Nano-LS/MS Analysis and Its Anti-Inflammatory Activity

Issue information | Evid Based Complement Alternat Med. 2019 Nov 4;2019:4683272. doi: 10.1155/2019/4683272. eCollection 2019.

Co-author | Venu Venkatarame Gowda Saralamma, Preethi Vetrivel, Seong Min Kin, Sang Eun Ha, Ho Jeong Lee, Sang Joon Lee, Young Sil Kim, Jung Eun Pak, HyeJin Lee, Jeong Doo Heo, and Gon Sup Kim

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Membrane-Free Stem Cell Components Inhibit Interleukin-1α-Stimulated Inflammation and Cartilage Degradation in vitro and in vivo: A Rat Model of Osteoarthritis

Issue information | Int J Mol Sci. 2019 Sep 30;20(19):4869.doi: 10.3390/ijms20194869.

Co-author | Ho Jeong Lee, Seon Min Lee, Yeon Gyu Moon, Yeon Seop Jung, Ju Hong Lee, Venu Venkatarame Gowda Saralamma, Young Sil Kim, Jung Eun Pak, Hye Jin Lee, Gon Sup Kim, Jeong Doo Heo

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A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia

Issue information | Stem Cells Translational Medicine. 2020 Aug;9(8):839-849.doi: 10.1002/sctm.19-0410. Epub 2020 May 18.

Co-author | Young Jin Tak, Sang Yeoup Lee, A Ra Cho, Young Sil Kim

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Membrane Free Stem Cell Extract from Adipose Tissue Enhances Glucose Uptake in 3T3-L1 Cells

Issue information | J Korean Med Obes Res 2019;19(2):89-96 https://doi.org/10.15429/jkomor.2019.19.2.89

Co-author | Ji Hyun Kim, Min Jeong Kim, Hye Sook Park, Young Sil Kim, Eun Ju Cho

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Protective Effect of Membrane-Free Stem Cell Extract against Oxidative Stress in LLC-PK1 Cells

Issue information | Journal of the Korea Academia-Industrial cooperation Society Vol. 20, No. 8 pp. 303-312, 2019

Co-author | Min Jeong Kim, Ji Hyun Kim, Hye Sook Park, Young Sil Kim, Eun Ju Cho

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Protective Effects of Membrane-Free Stem Cell Extract from H2O2-Induced Inflammation Responses in Human Periodontal Ligament Fibroblasts

Issue information | Journal of the Korea Academia-Industrial cooperation Society Vol. 20, No. 6 pp. 95-103, 2019

Co-author | Mei Tong He, Ji Hyun Kim, Young Sil Kim, Hye Sook Park, Eun Ju Cho

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Cellular Function of Annexin A1 Protein Mimetic Peptide Ac2-26 in Human Skin Keratinocytes HaCaT and Fibroblast Detroit 551 Cells

Issue information | Nutrients. 2020 Oct 24;12(11):3261. doi: 10.3390/nu12113261.

Co-author | Seong Min Kim, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jung Eun Park, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim

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Neuroprotective Effect of Membrane-Free Stem Cell Extract against Amyloid Beta 25–35-Induced Neurotoxicity in SH-SY5Y Cells

Issue information | Appl. Sci. 2021, 11(5), 2219; https://doi.org/10.3390/app11052219

Co-author | Hye Sook Park, Qi Qi Pang, Young Sil Kim, Ji Hyun Kim, Eun Ju Cho

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Protective Effect of Membrane-Free Stem Cells against Lipopolysaccharide and Interferon-Gamma-Stimulated Inflammatory Responses in RAW264.7 Macrophages

Issue information | Int J Mol Sci. 2021 Jun 27;22(13):6894. doi: 10.3390/ijms22136894.

Co-author | Mei Tong He, Hye Sook Park, Young Sil Kim, Ah Young Lee, Eun Ju Cho

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Inhibitory effect of membrane-free stem cell components derived from adipose tissues on skin inflammation in keratinocytes

Issue information | Mol Med Rep. 2022 Apr;25(4):125. doi: 10.3892/mmr.2022.12641.

Co-author | Sang Eun Ha, Preethi Vetrivel, Seong Min Kim, Pritam Bhagwan Bhosale, Hun Hwan Kim, Jung Eun Pak, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim

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Membrane-Free Stem Cells and Pyridoxal 5′-Phosphate Synergistically Enhance Cognitive Function in Alzheimer’s Disease Mouse Model

Issue information | Antioxidants (basel). 2022 Mar 21;11(3):601. doi: 10.3390/antiox11030601.

Co-author | Ji Myung Choi, Hye Sook Park, Mei Tong He, Young Sil Kim, Hyun Young Kim, Ah Young Lee, Eun Ju Cho

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Membrane-Free Stem Cell Extract Enhances Blood-Brain Barrier Integrity by Suppressing NF-KB-mediated Activation of NLRP3 inflammasome in Mice with Ischemic Stroke

Issue information | Life (Basel). 2022 Mar 29;12(4):503. doi: 10.3390/life12040503.

Co-author | Ji Hyeon Ryu, Yeonye Kim, Min Jae Kim, Jisu Park, Ji Won Kim, Hye Sook Park, Young Sil Kim, Hwa Kyoung Shin, Yong-Il Shin

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Clinical efficacy of membrane-free stem cell extracts for the treatment of canine atopic dermatitis

Issue information | Veterinarni Medicina. 2022, 67, 463-470. doi: 10.17221/136/2021-VETMED.

Co-author | Young Sil Kim, Sang Eun Ha, Hyeona Bae, Dongbin Lee, DoHyeon Yu, Gon Sup Kim

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Placebo-Controlled Clinical study of Membrane-Free Stem Cell Extract in Dogs with Osteoarthritis

Issue information | Anncaserep. 2022, Volume 7 Article 2358. doi: 10.25107/2474-1655.2358.

Co-author | Kim YS, Yoon MJ, Lee SJ and Kim GS

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Potential Joint Protective and Anti-Inflammatory Effects of Integrin αvβ3 in IL-1β-Treated Chondrocytes Cells

Issue information | biomedicines. 2023,11(10), 2745. doi: 10.3390/biomedicines11102745.

Co-author | Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Hyun Wook Kim, Je Kyung Seong, Meejung Ahn, Kwang Il Park, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim

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Membrane-free stem cell components ameliorate atopic dermatitis in 2,4-dinitrochlorobenzene-induced NC/Nga mice

Issue information | Dermatologica Sinica 41(4):p 238-250, Oct–Dec 2023. doi: 10.4103/ds.DS-D-23-00070.

Co-author | Stalin, Nattan; Lee, Dongyup; Sharma, Amitesh; Devi, Shivani; Choi, Jiwon; Hwang, Yunbhin; Kim, Young Sil; Park, Tae-Sik

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Treatment of canine pancreatitis using membrane-free stem cell extract and its anti-inflammatory effect

Issue information | Vet. Sci., Sec. Comparative and Clinical Medicine, Volume 12, 2025. doi: 10.3389/fvets.2025.1590703.

Co-author | Yongsoo Choi, Miae Lee, BoMyoung Kim, Youngsil Kim

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